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Antihistamine Interactions with Other Sedating Medications: What You Need to Know
Medication Guides

Antihistamine Interactions with Other Sedating Medications: What You Need to Know

  • 1 November, 2025
  • by Juliet Hargrove

Combining first-gen antihistamines like Benadryl with sleep aids, opioids, or alcohol can cause dangerous sedation and breathing problems. Learn why second-gen options like Claritin and Allegra are safer, who’s at risk, and what to do instead.

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