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Tag: opioid-induced pruritus

Opioid-Induced Itching: How Histamine and Nerve Pathways Trigger It - And What Actually Works
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Opioid-Induced Itching: How Histamine and Nerve Pathways Trigger It - And What Actually Works

  • 15 November, 2025
  • by Juliet Hargrove

Opioid-induced itching affects up to 100% of patients receiving spinal opioids. It's not caused by histamine as once thought - but by direct nerve activation. Learn what actually works to stop it, and why common treatments like Benadryl often fail.

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